Details of the Drug

General Information of Drug (ID: DMOEVK6)

Drug Name
Ammonia
Synonyms Ammonia N13
Indication
Disease Entry ICD 11 Status REF
Coronary artery disease BA80 Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 17.031
Topological Polar Surface Area (xlogp) -0.7
Rotatable Bond Count (rotbonds) 0
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 1
ADMET Property
Half-life
The concentration or amount of drug in body reduced by one-half in 3 seconds [2]
Metabolism
The drug is metabolized via the hepatic [3]
Chemical Identifiers
Formula
H3N
IUPAC Name
azane
Canonical SMILES
N
InChI
InChI=1S/H3N/h1H3
InChIKey
QGZKDVFQNNGYKY-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
222
ChEBI ID
CHEBI:16134
CAS Number
7664-41-7
DrugBank ID
DB11118
TTD ID
D0FT7Y
VARIDT ID
DR00194
INTEDE ID
DR0100

Molecular Interaction Atlas of This Drug


Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Ammonium transporter Rh type C (SLC42A3) DTF3LTV RHCG_HUMAN Substrate [4]
Ammonium transporter Rh type B (SLC42A2) DTU6IF7 RHBG_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Glutamine synthetase (GLUL)
Main DME 		DE5UC73 GLNA_HUMAN Substrate [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
2 Ammonia - National Library of Medicine HSDB Database - Toxnet - NIH
3 Agarwal SK, Hu B, Chien D, Wong SL, Salem AH: Evaluation of Rifampin's Transporter Inhibitory and CYP3A Inductive Effects on the Pharmacokinetics of Venetoclax, a Bcl-2 Inhibitor: Results of a Single- and Multiple-dose Study. J Clin Pharmacol. 2016 Mar 7. doi: 10.1002/jcph.730.
4 Functional analysis of human RhCG: comparison with E. coli ammonium transporter reveals similarities in the pore and differences in the vestibule. Am J Physiol Cell Physiol. 2009 Sep;297(3):C537-47.
5 Ammonia metabolism capacity of HepG2 cells with high expression of human glutamine synthetase. Hepatobiliary Pancreat Dis Int. 2008 Dec;7(6):621-7.